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  • Product Des


Recombinant Human Growth Hormone for Injection
Please read Package Insert carefully and administer under the guidance of physicians
●Generic Name:Recombinant Human Growth Hormone
●Recombinant human growth hormone and excipients
●Molecular Formula: C990H1528N262O300S7 with 191 amino acid residues
●Molecular Weight: 22125D
●Origin of the Active Ingredient:XINTPOPIN is a Recombinant human growth hormone (rhGH) produced by gene recombination E.COLI secretion expression technology. Its precursor synthesized in E.COLI including gene of human grow hormone (hGH) was secreted to periplasmic space of the cell guided under signal peptide. The signal peptide was removed and polypeptide molecule is folded exactly to growth hormone (GH) molecule. XINTROPIN has 191 amino acid residues and a molecular weight of 22125 daltons. Its amino acid content, structure and sequence are identical to those of hGH.
●White lyophilized powder
●Growth hormone deficiency (GHD) due to diseases of hypothalamus-pituitary gland
●severe burns
●In adults with growth hormone deficiency, XINTROPIN in reduces fat mass, increases muscle mass and improve senergy, vitality and subjective well-being. Inpatients suffering from severe burns, AIDS associated muscle wasting, or under going major operations, XINTROPIN promotes wound healing, attenuates the protein-catabolic response and improves whole-body nitrogen condition after operation.

●Before administration, add 1ml of sterile water for injection to the rhGH vial of lyophilized powder, along the wall slowly. Shake it gently to fully dissolve the powder to get clarified solution. Do not shake violently.
●For anti-aging, general health&healing, fat mobilization, a dose do 2-3IU's per day will be sufficient for the majority. A dose of 1.5 to 2.0 IU's is considered to be a full replacement dose for those in their middle-age and beyond.
●For gaining lean muscle and substantially improving body compositing, a dose of 4-8IU's per day will be necessary, Most people will respond very well at a dose of 4-5IU's per day. For maximun benefit in this regard the addition of Testosterone, Insulin, and low-dose t3 would be something to seriously consider. More on this in our comparative cycle guide of HGH/Insulin/IGF.
●The recommended dosage for injection is 0.1-0.15IU/kg/day, inject before sleeping daily at the same time and the injection site should be changes frequently to prevent lipoatrophy at the site, or follow the physician's advice.
●Growth hormone may induce transient hyperglycosemia, which usually recover to normal level over time or after drug discontinuation.
●About 1-3% children with microsomia in the clinical trials presented side effects, which usually presented transient reactions at the injection site (pain, tingling numbness,red swelling,ect) and the symptoms of fluid retention (peripheral edema,arthralgia or myalgia), These side effects usually appear stage and the incidence rate decreases over time which rarely affects daily activities.
●Long-term injection of recombinant human growth hormone results in antibody production in minority people, however,the affinity of the antibody is low without exact clinical significance. The antibody may be induced if the anticipant effect of growth is not achieved, which may effect the efficacy if the affinity is over 2mg/L, it might interfere with the treatment.
●children with closure of epiphysis are forbidden.
●Patients with the progressive symptoms of tumor are forbidden.
●Critical ill patients with severe generalized infections are forbidden.
●rhGH therapy should be conducted on exactly diagnosed GHD patients under advice of experienced doctor.
●For diabetes patients, dosage of anti-diabetic drugs should be adjusted during rhGH therapy.
●For patients whose GHD were caused by encephaloma or encephalic wound, the progress and relapse possibility of potential diseases should be closely monitored.
●For ACTH deficiency patients, dosage of ACTH should be adjusted because the growth improvement effect of rhGH could be inhibited by simultaneous using of ACTH.
●Thyroid gland function should be tested regularly,because clinical hypothyroidism may occur to some patients during rhGH therapy. For those hypothyroid, thyroid supplementation is necessary for ensuring the therapeutic effects of rhGH.
●Careful consideration should be taken if claudicating occurred during rhGH therapy because the patients who suffered from endocrine syetem disease (including GHD) have such a tendency that their epiphysis plates of femur are relatively easy to separate.
●Growth hormone may lead to over insulin state, Attention should be paid to if lower glucose intolerance appeared.
●Do not take over dose of rhGH, one time over-dose rhGH administration can lead to high blood sugar. Long-term over-dose rhGH administration can lead to acromegaly.
●Injection site should often variation in case lipoatrophy.
●Athletes should administer with caution.
●It should not be used for women in pregnancy and lactation.
●There is no significant difference in pharmacology and pharmacokinetics between children and adults. Administer safely according to weights.
●There is no clinical report in senior population.
●Simultaneous glucocorticoid therapy might inhibit the effect of hGH. Generally, the dose of glucocorticoid can not exceed 10-15mg CORT/M2 of surface areas. Growth rate can be increased by combination with other non-androgen steroids.
●Concurrent administration of non androgen steroids may further promote the growth rate.
●There is no report on acute overdose. Overdose could lead to initially hypoglycemia and subsequently hyperglycemia. Long-term overdose could result in symptoms of acromegaly, consistent with the known effects of excessive GH.
●rhGH exerts the same actions of endogenous human growth hormone, It can stimulate proliferation and differentiation of epiphysis chondrocyte, stimulate growth of cartilage matrix cells, stimulate proliferation and differentation of osteoblast; thus accelerate the liner growth rate and improve epiphysis width.
●rhGH can promote protein synthesis in whole body reverse the negative nitrogen equilibrium caused by wound and suger; correct the hypoproteinemia due to severe infection or hepatocirrhosis; stimulate synthesis of immune globin and proliferation of lymph adenoid, macrophage and lymphocyte, thus enhance the ability of infection resistance; stimulate proliferation of collagen oocyte, fibroblast and macrophage in sites of burn and surgery, thus accelerate wound healing; promote synthesis of cardiocytes, thus improve cardiac contractility and reduce caria oxygen consumption; regulate lipometabolism, tbus depress serum cholesterol and low density lipoproteins level; complement insufficiency or deficiency of grow hormone, regulate adult's lipometabolism,osteo metabolism, heart and kidney function.
●It has been reported in literature that the therapeutic effects are the same for both subcutaneously and intramuscularly administrations. Usually subcutaneously administration causes higher concentration of IGF-I are the same with these two approaches of administration. Generally, the absorption of GH is slow. The concentration of GH in plasma reaches the peak after 3-5 hours of administration; usually elimination half-time is 2-3 hours. GH is eliminated through liver and kidney, and the process in adults is faster than that in children. Non-metabolized GH eliminated directly directly through urine is very little.
●Almost all GH in the blood circulation is bound to the high affinity GH binding protein(hGHBP), which increases the half life of GH serum. Different injection time dose not influence the concentration of GH in serum.
●Store and transport at 2-8℃. protect from light
●Before reconstitution:
--If refrigerated between 2-8℃ it's good until expiration date.
--At room temperature(under<30℃) it's good for over 20days.
●After reconstitution:
--Use Bacteriostatic Water to reconstitute and keep in 2-8℃, it will be good for <10day.
--Use Sterile Water to reconstitute and keep in 2-8℃, it will be good for 72 hours.
●Glass vials: 10vials/pack

●Fulfill with EP2005 Specifications
●Xin Chen Biological Engineering Co., Ltd
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